Associations Between Microbiota, Mitochondrial Function, and Cognition in Chronic Marijuana Users

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Striatal dopamine levels and changes in mitochondrial function following chronic 3-nitropropionic acid treatment in rats

An irreversible inhibitor of complex II in the mitochondria, 3-nitropropionic acid (3-NP), induces bilateral striatal lesions with many neuropathological features of Huntington’s disease (HD) in rats. It is widely used as a model of HD. Chronic systemic treatment of 3-NP for 4 days in rats (10, 15 and 20 mg/kg) caused a significant dose-dependent reduction in succinate dehydrogenase activity, w...

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Striatal dopamine levels and changes in mitochondrial function following chronic 3-nitropropionic acid treatment in rats

An irreversible inhibitor of complex II in the mitochondria, 3-nitropropionic acid (3-NP), induces bilateral striatal lesions with many neuropathological features of Huntington’s disease (HD) in rats. It is widely used as a model of HD. Chronic systemic treatment of 3-NP for 4 days in rats (10, 15 and 20 mg/kg) caused a significant dose-dependent reduction in succinate dehydrogenase activity, w...

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EEG of chronic marijuana users during abstinence: relationship to years of marijuana use, cerebral blood flow and thyroid function.

OBJECTIVE Marijuana abuse is associated with neurological changes including increases in frontal EEG alpha during abstinence. Research is needed to assess to what extent these EEG patterns are indicative of cerebral perfusion deficits. METHODS We recorded the resting eyes closed EEG of 75 abstinent marijuana users and 33 control subjects. Fifty-six marijuana users used marijuana for less than...

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Associations between Periodontal Microbiota and Death Rates

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Decreased depression in marijuana users.

Over 4400 adult internet users completed The Center for Epidemiologic Studies Depression scale and measures of marijuana use. We employed an internet survey in an effort to recruit the most depressed and marijuana-involved participants, including those who might prove unwilling to travel to the laboratory or discuss drug use on the phone or in person. We compared those who consumed marijuana da...

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ژورنال

عنوان ژورنال: Journal of Neuroimmune Pharmacology

سال: 2017

ISSN: 1557-1890,1557-1904

DOI: 10.1007/s11481-017-9767-0